Molecular MS Diagnostics, LLC

About MMSD

The MMSD Edge

Our Services

Capabilities

Let the competent team of scientists at MMSD streamline your analysis.

Molecular MS Diagnostics is an emerging analytical/bioanalytical laboratory providing a variety of testing services. We offer pharmaceutical sample analyses to meet the needs of your company in an efficient and cost-effective manner.

Assays, developed at the pre-clinical stage, can be the cohesive force in integrating a program from pre-clinical to early clinical through proof-of-concept studies—and beyond. The scientists at MMSD have had exposure to a wide variety of assay applications and their respective data, and are well positioned to offer guidance on selection and assay technology limitations.

Services Available:

Analytical Services:

Assay and impurity HPLC testing for drug substance, drug products
Method development, verification/validation, method transfer
Dissolution Testing

Bioanalytical Services:

Plasma/Blood Stability Assays
Plasma and Urine Analysis of Generic drugs and NCE's
LC-MS/MS method development, Verification/Validation, Method Transfer

SAMPLE PREP TIPS

Never heat frozen plasma in a water bath to hasten thawing, as this will cause unwanted protein precipitation. Allow it to thaw out at room temperature, just plan ahead.
When investigation drug-in-plasma stability, be sure to perform at least three freeze cycles, otherwise you may find unexpected surprises caused by drug solubility and/or matrix instability. Be diligent in this step during method development.
To solve carryover problems, always chose a wash solvent/solvents most soluble for your analyte. The best approach is to wash with the most soluble, non-polar solvent, followed by the most soluble polar (aqueous) solvent. Differences in pH can have a dramatic effect on analyte solubility, so chose the pH of your polar solvent wisely.

METHOD DEVELOPMENT TIPS

Don't reinvent the wheel! Do some research to see what others have already developed. This will provide a proven base to develop your method fast.
Know what your analyte is soluble in and how it may behave with changes in pH. And never assume it is soluble in a typical nonpolar solvent. The solubility should also be determined through testing.
A thorough understanding of detectors and their various settings will aid in choosing which system will work best with your particular analyte. Switching to a more selective wavelength can help reveal what may be co-eluting or increase selectivity.
After demonstrating precision and accuracy, be sure to perform an analyte degradation analysis to establish stability indicators as early as possible.

NEWS & EVENTS

	MMSD Celebrates 1st-Year Anniversary (Press Release)
Look for MMSD at the following meetings and events: ASMS 2008 Jun 1-5 CPSA 2008 Oct 27-30 AAPS 2008 Nov 16-20 MMSD opens analytical and bioanalytical testing facility in Cranston, RI in May of 2007

Privacy and Security Notice